Golden oyster mushrooms (Pleurotus citrinopileatus) is an edible fungus famous for their striking golden hue and delicate, nutty flavor. It offers numerous health benefits, including immune support, antioxidant properties, and potential cholesterol-lowering effects. In biotechnology, golden oyster is a treasure trove of bioactive compound, including polysaccharides, glycoproteins, ergothioneine and glutathione, which collectively contribute to its potent antioxidant, anti-inflammatory and immunomodulatory properties .